In 2013, she played background or supporting roles in each series, such as Stella Women’s Academy, High School Division Class C³, Driland and Aikatsu. She also played the role of a student in a voiced comic stream of the online manga Pokémon Card Game XY: Yarouze!. In 2015, she played her first lead role as Futaba Ichinose in the anime television series Seiyu’s Life!. Takahashi, together with Seiyu’s Life! co-stars Marika Kouno and Yuki Nagaku, formed the musical unit Earphones. That same year, she was cast as the characters Miki Naoki in School-Live! and Kaon Lanchester in Comet Lucifer. She and fellow School-Live! co-stars Inori Minase, Ari Ozawa, and Mao Ichimichi, performed the series’ opening theme “Friend Shitai” (ふ・れ・ん・ど・し・た・い , I Want to be Friends) . In March 2016, Takahashi received the Best Newcomer Award at the 10th Seiyu Awards. She was then cast as the character Megumin in the anime series KonoSuba; she and co-stars Sora Amamiya and Ai Kayano performed the series’ closing theme “Chiisana Boukensha” (ちいさな冒険者 , Little Adventurer) . She also voiced the roles of Noct Leaflet in Undefeated Bahamut Chronicle, OL in Digimon Universe: Appli Monsters, Mirai Asahina in Maho Girls PreCure!, and Code Omega 00 Yufilia in Ange Vierge. She then played the role of Emilia in the anime series Re:Zero − Starting Life in Another World; Takahashi also performed the series’ second closing theme “Stay Alive”. Later that year, she was cast as the character Mash Kyrielight in the mobile phone game Fate/Grand Order, replacing Risa Taneda who had gone on hiatus earlier that year. In 2017, Takahashi reprised the role of Megumin in the second season of KonoSuba, where she, Amamiya and Kayano performed the series’ closing theme “Ouchi ni Kaeritai” (おうちに帰りたい , I Wanna Go Home) . She also played the roles of Aqua Aino in Love Tyrant, and Ernesti Echevarria in Knight’s & Magic. In 2018, she played the role of Takagi-san in the anime series Teasing Master Takagi-san, where she also performs the series’ closing themes. She also played the roles of Tsubasa Katsuki in Comic Girls and Sagiri Ameno in Yuuna and the Haunted Hot Springs. In 2019, she played the role of Nozomi Makino in Magical Girl Spec-Ops Asuka. and reprised her role as Takagi-san in Teasing Master Takagi-san, where she also performs the series’ closing themes.